Article
Sex-specific autosomal susceptibility loci in systemic sclerosis: a genome-wide association study.
The Lancet. Rheumatology - 1 Jun 2026
Rodriguez-Martin Inmaculada, Kerick Martin, Rangel-Peláez Carlos, Rosa-Baez Carlos, Borrego-Yaniz Gonzalo, Ortiz-Fernández Lourdes, Guillen-Del-Castillo Alfredo, Simeón-Aznar Carmen P, Callejas José Luis, Distler Oliver, Proudman Susanna M, Nikpour Mandana, Hunzelmann Nicolas, de Vries-Bouwstra Jeska K, Herrick Ariane L, Allanore Yannick, Alarcón-Riquelme Marta E, Beretta Lorenzo, Assassi Shervin, Denton Christopher P, Mayes Maureen D, Martin Javier, Acosta-Herrera Marialbert
Abstract excerpt
BACKGROUND: Systemic sclerosis is an immune-mediated inflammatory disease with marked sex differences in prevalence and severity. Although genome-wide association studies (GWAS) have advanced the understanding of systemic sclerosis genetics, sex-aware approaches remain scarce. We aimed to address this gap by examining autosomal sex-specific genetic factors in systemic sclerosis. METHODS: Based on a chromosomal...
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