Article

ZnF-UBP domains regulate deubiquitinase activity by relieving ubiquitin product inhibition

2025-09-29

Abstract excerpt

Most ubiquitin specific protease (USP) deubiquitinases (DUBs) combine non-selective catalytic domains with one or multiple ‘exo’-domains that contribute substrate specificity and localisation, but are generally poorly characterised. Zinc-Finger UBP (ZnF-UBP) domains exist in 12 USP DUBs, yet their function is unclear. We here comprehensively analyse human ZnF-UBP domains, and reveal that 8 of 14 bind ubiquitin (Ub...

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Literature Corpus work: 021faa13-810a-593c-9615-8255bbcc6e33
DOI: 10.1101/2025.09.28.679104

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