Article
The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1.
Current biology : CB - 12 Jul 2005
Hetfeld Bettina K J, Helfrich Annett, Kapelari Barbara, Scheel Hartmut, Hofmann Kay, Guterman Adi, Glickman Michael, Schade Rüdiger, Kloetzel Peter-Michael, Dubiel Wolfgang
Abstract excerpt
The COP9 signalosome (CSN) is a conserved protein complex found in all eukaryotic cells and involved in the regulation of the ubiquitin (Ub)/26S proteasome system. It binds numerous proteins, including the Ub E3 ligases and the deubiquitinating enzyme Ubp12p, the S. pombe ortholog of human USP15. We found that USP15 copurified with the human CSN complex. Isolated CSN complex exhibited protease activity that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.