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TRPM2 regulates cell cycle through the Ca2+-CaM-CaMKII signaling pathway to promote HCC

14 Apr 2023

Abstract excerpt

BACKGROUND: HCC is one of the most common causes of cancer-related deaths. Transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable cation channel, was reported to be involved in carcinogenesis and tumor growth recently. However, whether TRPM2 is involved in the pathogenesis and progression of HCC remains unclear. Herein, we systematically elucidated the functional role of TRPM2 in HCC cell cycle...

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PMID: 37058100
DOI: 10.1097/hc9.0000000000000101

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