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Article

Roles of TRPM8 Ion Channels in Cancer: Proliferation, Survival, and Invasion

23 Oct 2015

Abstract excerpt

The goal of this article is to provide a critical review of the transient receptor potential melastatin-subfamily member 8 (TRPM8) in cancers, with an emphasis on its roles in cellular proliferation, survival, and invasion. The TRPM8 ion channels regulate Ca²⁺ homeostasis and function as a cellular sensor and transducer of cold temperature. Accumulating evidence has demonstrated that TRPM8 is aberrantly expressed...

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Identifiers

PMID: 26512697
DOI: 10.3390/cancers7040882

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