Article

A bidirectional interaction between the SREBP pathway and the LINC complex component nesprin-4 controls lipid metabolism

2026-04-21

Abstract excerpt

This report identifies a bidirectional signaling axis connecting lipid metabolism to nuclear mechanotransduction, with the potential to control fatty acid/triglyceride metabolism. The sterol regulatory element-binding (SREBP) family of transcription factors control fatty acid, triglyceride and cholesterol synthesis and metabolism. The family consists of three members: SREBP1a, SREBP1c, and SREBP2, that are regulat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 01baa66c-c087-52c7-a54f-c2ab9833022b
DOI: 10.64898/2026.04.18.719359

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A bidirectional interaction between the SREBP pathway and the LINC complex component nesprin-4 controls lipid metabolismDOI 10.64898/2026.04.18.719359Read

Therapeutic strategies targeting SREBP transcription factors: an update to 2024Semantic proximity Read

The roles and mechanisms of SREBP1 in cancer development and drug responseSemantic proximity Read

Genome-Wide Occupancy of SREBP1 and Its Partners NFY and SP1 Reveals Novel Functional Roles and Combinatorial Regulation of Distinct Classes of GenesSemantic proximity Read

Identification of the novel role of sterol regulatory element binding proteins (SREBPs) in mechanotransduction and intraocular pressure regulationSemantic proximity Read

Role of endothelial cells in pulmonary fibrosis via SREBP2 activationSemantic proximity Read

Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytesSemantic proximity Read

Emerging roles of the myocardin family of proteins in lipid and glucose metabolismSemantic proximity Read

Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscleSemantic proximity Read

Coordinate Regulation of Lipid Metabolism by Novel Nuclear Receptor PartnershipsSemantic proximity Read

Regulation of Cholesterol Homeostasis by a Novel Long Non-coding RNA LASERSemantic proximity Read

Atrial fibrillation associated common risk variants in SYNE2 lead to lower expression of nesprin-2α1 and increased nuclear stiffnessSemantic proximity Read

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolismSemantic proximity Read