Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GWAS on short tandem repeats identifies genetic mechanisms in Alzheimer's disease.

Nature communications - 4 Jun 2026

Gmelin David, Ohlei Olena, Aslam M Muaaz, Junge Marit P, Parkkinen Laura, Mullin Kristina, Prokopenko Dmitry, Lill Christina M, Tanzi Rudolph E, Dobricic Valerija, Bertram Lars

Abstract excerpt

GWAS typically focus on SNPs, often excluding complex genetic variants, such as short tandem repeats. Here, we report the results of GWAS analyses systematically assessing the role of short tandem repeats, both imputed and directly genotyped by whole genome sequencing, on risk for Alzheimer's disease in a large collection of ~330,000 individuals (3287 cases; 47,048 Alzheimer's disease-by-proxy cases, 283,111...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Microsatellite Repeats
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Genotype

Share to Polymorphism, Single Nucleotide

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 42243151
DOI: 10.1038/s41467-026-73902-7
PMCID: PMC13237113

Genes

ABCA7
ADAM10
APOE
SNX32

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GWAS on short tandem repeats identifies genetic mechanisms in Alzheimer's disease.PMID 42243151Read ↗

GWAS on short tandem repeats identifies novel genetic mechanisms in Alzheimer’s diseaseSemantic proximity Read ↗

Polygenic burden of short tandem repeat expansions promote risk for Alzheimer’s diseaseSemantic proximity Read ↗

Polygenic burden of short tandem repeat expansions promotes risk for Alzheimer's disease.Semantic proximity Read ↗

Rare coding variants from ADSP R5 whole-genome sequencing implicate novel genes in Alzheimer’s diseaseSemantic proximity Read ↗

Key variants via Alzheimer’s Disease Sequencing Project whole genome sequence dataSemantic proximity Read ↗

Genome-wide contribution of common short-tandem repeats to Parkinson's disease genetic risk.Semantic proximity Read ↗

Whole-genome sequencing reveals new Alzheimer’s disease-associated rare variants in loci related to synaptic function and neuronal developmentSemantic proximity Read ↗

Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data.Semantic proximity Read ↗

Association of Common and Rare Variants with Alzheimer’s Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer’s Disease Sequencing ProjectSemantic proximity Read ↗

A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution.Semantic proximity Read ↗

Revisiting tandem repeats in psychiatric disorders from perspectives of genetics, physiology, and brain evolution.Semantic proximity Read ↗

Genome-wide contribution of common Short-Tandem Repeats to Parkinson’s Disease genetic riskSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.