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Article

Short tandem repeat expansions in patients with neurodegenerative dementia.

EBioMedicine - 1 Mar 2026

Zhu Yuan, Xiao Xuewen, Liu Yiliang, Wang Zheng, Luo Tengfei, Xu Tianyan, Yang Qijie, Hao Xiaoli, Zhang Cong, Zhang Sizhe, Luo Shilin, Zhou Yafang, Liao Xinxin, Tian Yun, Weng Ling, Fang Liangjuan, Tang Beisha, Jiao Bin, Li Jinchen, Shen Lu

Abstract excerpt

BACKGROUND: Due to the overlapping clinical features of neurodegenerative dementia (NDD)-including Alzheimer's disease (AD), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), and progressive supranuclear palsy (PSP), accurate diagnosis remains challenging in early stages. Multiple dementias can be caused by short tandem repeat (STR) expansions. However, systematic investigation of known pathogenic...

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Source

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Identifiers

PMID: 41762523
DOI: 10.1016/j.ebiom.2026.106190
PMCID: PMC12962126

Genes

AR
CACNA1A
DMPK
FMR1
HTT
NOTCH2NLC
TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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