Article

Melanopsin regulates axonal translation underlying retinohypothalamic circuit assembly

2026-04-23

Abstract excerpt

Intrinsically photosensitive retinal ganglion cells (ipRGCs) influence visual system development via melanopsin before photoreceptor-mediated vision, but how melanopsin signaling contributes to ipRGC circuit assembly remains unknown. Here we show that melanopsin coordinates retinohypothalamic tract development by regulating local translation in developing ipRGC axons. Loss of melanopsin selectively disrupted local...

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Identifiers and source

Literature Corpus work: 0187303f-1076-5e19-ada2-672fd03d125e
DOI: 10.64898/2026.04.21.716817

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