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<i>SFPQ-TFE3</i> gene fusion reciprocally regulates mTORC1 activity and induces lineage plasticity in a novel mouse model of renal tumorigenesis

2024-11-22

Abstract excerpt

<h4>Summary</h4> The MiT/TFE family gene fusion proteins, such as SFPQ-TFE3 , drive both epithelial (eg, translocation renal cell carcinoma, tRCC) and mesenchymal (eg, perivascular epithelioid cell tumor, PEComa) neoplasms with aggressive behavior. However, no prior mouse models for SFPQ-TFE3 -related tumors exist and the mechanisms of lineage plasticity induced by this fusion remain unclear. Here, we demonstra...

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Literature Corpus work
53dd054f-2739-53ab-89ef-3429f0ef65bb
DOI
10.1101/2024.11.21.624702
Open publication

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