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MiT family translocation renal cell carcinoma in an elderly male

1 Jul 2021

Abstract excerpt

Translocation-associated renal cell carcinoma (t-RCC) is a relatively uncommon subtype of renal cell carcinoma characterized by recurrent gene rearrangements involving the TFE3 or TFEB loci. TFE3 and TFEB are members of the microphthalmia transcription factor (MiT) family, which regulate differentiation in melanocytes and osteoclasts. Renal cell carcinomas (RCCs) associated with Xp11 translocations have gene...

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PMID: 34341271
DOI: 10.4103/ijpm.ijpm_365_20

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