Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Murine Model of K-RAS and β-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor.

The Journal of urology - 1 Dec 2015

Yi Yajun, Polosukhina Dina, Love Harold D, Hembd Austin, Pickup Michael, Moses Harold L, Lovvorn Harold N, Zent Roy, Clark Peter E

Abstract excerpt

PURPOSE: Wilms tumor is the most common renal neoplasm of childhood. We previously found that restricted activation of the WNT/β-catenin pathway in renal epithelium late in kidney development is sufficient to induce small primitive neoplasms with features of epithelial Wilms tumor. Metastatic disease progression required simultaneous addition of an activating mutation of the oncogene K-RAS. We sought to define...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to E2F1 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney

Share to Kidney Neoplasms

Share to Mice, Mutant Strains

Share to Transcriptional Activation

Share to Up-Regulation

Share to Wilms Tumor

Source

Open in PubMed Open full text

Identifiers

PMID: 25934441
DOI: 10.1016/j.juro.2015.04.090
PMCID: PMC4782590

Genes

FOXA2
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Murine Model of K-RAS and β-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor.PMID 25934441Read ↗

β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.Semantic proximity Read ↗

Stromal β-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor.Semantic proximity Read ↗

Renal Tubular Epithelium in the Development of Renal Cell CarcinomaSemantic proximity Read ↗

Nephron Progenitor But Not Stromal Progenitor Cells Give Rise to Wilms Tumors in Mouse Models with β-Catenin Activation or Wt1 Ablation and Igf2 Upregulation.Semantic proximity Read ↗

β-Catenin overexpression in the metanephric mesenchyme leads to renal dysplasia genesis via cell-autonomous and non-cell-autonomous mechanisms.Semantic proximity Read ↗

Wilms' tumor gene 1: lessons from the interface between kidney development and cancer.Semantic proximity Read ↗

Temporal blastemal cell gene expression analysis in the kidney reveals new Wnt and related signaling pathway genes to be essential for Wilms' tumor onsetSemantic proximity Read ↗

Analysis of TFEB function in Ksp-Cadherin16 CRE mouse lines to model a particular type of renal cell carcinomaSemantic proximity Read ↗

Nephroblastoma (Wilms' tumor): a model system of aberrant renal development.Semantic proximity Read ↗

Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylationSemantic proximity Read ↗

Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers.Semantic proximity Read ↗

Integrative Transcriptomic Profiling Reveals Novel Biomarkers in Wilms TumorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.