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Low-Protein Diet Enhances Anti-Tumor Immunity and Immunotherapy through Microbiota-Derived Uridine Diphosphate-Galactose in Pancreatic Cancer

2025-01-29

Abstract excerpt

<title>Abstract</title> <p>This study explored the potential of a low-protein diet (LPD) to modulate the gut microbiota, focusing on pancreatic ductal adenocarcinoma (PDAC) progression and response to immunotherapy. A 25% reduction in dietary protein intake attenuated PDAC development, drove immune activation in the tumor microenvironment (TME) and boosted the immunostimulatory tumor-associated macrophages (TAMs)...

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Literature Corpus work
0113f3fd-cc13-50cd-878b-372cd5c28ce6
DOI
10.21203/rs.3.rs-5804694/v1
Open publication

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Low-Protein Diet Enhances Anti-Tumor Immunity and Immunotherapy through Microbiota-Derived Uridine Diphosphate-Galactose in Pancreatic CancerDOI 10.21203/rs.3.rs-5804694/v1
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