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Gut Microbiota inhibit the potency of MSLN-CAR-T cells against pancreatic carcinoma by modulating Cholesterol Metabolism

2026-07-27

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Pancreatic cancer is one of the gastrointestinal malignant tumors with the highest mortality rate in the world, and CAR-T immunotherapy has shown poor therapeutic efficacy for pancreatic cancer despite its promising applications. <bold>Methods</bold> In this study, we first collected fecal samples from 9 pancreatic cancer patients and 20 healthy individuals...

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Literature Corpus work
0a716256-556d-52e1-abad-1ebebe2f5f2e
DOI
10.21203/rs.3.rs-10451699/v1
Open publication

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Gut Microbiota inhibit the potency of MSLN-CAR-T cells against pancreatic carcinoma by modulating Cholesterol MetabolismDOI 10.21203/rs.3.rs-10451699/v1
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