Article

Systematic mediation and interaction analyses of kidney function genetic loci in a general population study

2023-04-23

Abstract excerpt

Chronic kidney disease (CKD) is a complex disease affecting >10% of the global population, with large between-and within-continent variability reflecting major environmental effects. To identify molecular targets for treatment, genome-wide association study meta-analyses (GWAMAs) of CKD-defining traits have identified hundreds of genetic loci in aggregated populations. However, while GWAMAs estimate the average al...

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Literature Corpus work: 01005e55-43a3-50b3-8baf-1ba80ffd71aa
DOI: 10.1101/2023.04.15.23288540

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