Article
A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level.
BMC medical genetics - 11 Mar 2010
Pattaro Cristian, De Grandi Alessandro, Vitart Veronique, Hayward Caroline, Franke Andre, Aulchenko Yurii S, Johansson Asa, Wild Sarah H, Melville Scott A, Isaacs Aaron, Polasek Ozren, Ellinghaus David, Kolcic Ivana, Nöthlings Ute, Zgaga Lina, Zemunik Tatijana, Gnewuch Carsten, Schreiber Stefan, Campbell Susan, Hastie Nick, Boban Mladen, Meitinger Thomas, Oostra Ben A, Riegler Peter, Minelli Cosetta, Wright Alan F, Campbell Harry, van Duijn Cornelia M, Gyllensten Ulf, Wilson James F, Krawczak Michael, Rudan Igor, Pramstaller Peter P
Abstract excerpt
BACKGROUND: Serum creatinine (S CR) is the most important biomarker for a quick and non-invasive assessment of kidney function in population-based surveys. A substantial proportion of the inter-individual variability in S CR level is explicable by genetic factors. METHODS: We performed a meta-analysis of genome-wide association studies of S CR undertaken in five population isolates ('discovery cohorts'), all of...
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