Article

Development and use of a mouse model to investigate β-lactam hypersensitivity reactions

2014-01-01

Abstract excerpt

β-lactam hypersensitivity reactions can be severe and are extremely difficult to predict. Drug-specific T-cells have been identified in blood of patients presenting with cutaneous and hepatic hypersensitivity reactions, indicating that they play a role in the disease pathogenesis. Animal models are highly effective tools that have been used extensively to dissect mechanisms of disease and pathways of disease progr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 00daf95e-31e1-51fe-8065-ceaa45a87302
DOI: 10.17638/00019433

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development and use of a mouse model to investigate β-lactam hypersensitivity reactionsDOI 10.17638/00019433Read

Characterisation of the phenotype and function of drug-responsive T-cells in patients with drug-induced liver injurySemantic proximity Read

Characterisation of the B-lymphocyte response in delayed-type piperacillin hypersensitivity reactionsSemantic proximity Read

Contribution of mouse models in our understanding of lupusSemantic proximity Read

Characterization of a cyclophosphamide-induced murine model of immunosuppression to study Acinetobacter baumannii pathogenesisSemantic proximity Read

Characterisation of drug-specific T-cell responses in hypersensitive patients and healthy donorsSemantic proximity Read

HLA transgenic mice: application in reproducing idiosyncratic drug toxicity.Semantic proximity Read

A novel mouse model for checkpoint inhibitor-induced adverse events.Semantic proximity Read

New Approaches to Investigate Drug-Induced Hypersensitivity.Semantic proximity Read

A transgenic mouse model for HLA-B*57:01–linked abacavir drug tolerance and reactivitySemantic proximity Read

The role of T-helper 17 and T-helper 22 lymphocytes in beta-lactam hypersensitivitySemantic proximity Read

Drug allergy.Semantic proximity Read

Prediction of hypersensitivity to antibiotics: what factors need to be considered?Semantic proximity Read