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Article

Analysis of 470,000 exome-sequenced UK biobank participants identifies genes containing rare variants which confer dementia risk.

Journal of neurogenetics - 1 Jan 2025

Gibbons Lily, Curtis David

Abstract excerpt

Previous studies have reported that rare coding variants in a handful of genes have major effects on risk of Alzheimer's disease (AD). A recent exome wide association study (ExWAS) of dementia in a subset of the UK Biobank cohort implicated a number of genes, including five which were novel. Here we report a similar analysis, carried out on the full cohort of 470,000 exome-sequenced participants. A score was...

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ATP-Binding Cassette Transporters
Biological Specimen Banks
Dementia
Exome Sequencing
LDL-Receptor Related Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Immunologic

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Identifiers

PMID: 40574547
DOI: 10.1080/01677063.2025.2522643

Genes

ABCA7
APOE
SORL1
TREM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Analysis of 470,000 exome-sequenced UK biobank participants identifies genes containing rare variants which confer dementia risk.PMID 40574547Read ↗

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