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A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors

5 Mar 2024

Abstract excerpt

Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6is) have revolutionized breast cancer therapy. However, <50% of patients have an objective response, and nearly all patients develop resistance during therapy. To elucidate the underlying mechanisms, we constructed an interpretable deep learning model of the response to palbociclib, a CDK4/6i, based on a reference map of multiprotein assemblies in cancer. The...

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PMID: 38443662
DOI: 10.1038/s43018-024-00740-1

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