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O‐GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance

30 May 2023

Abstract excerpt

DNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs, but clinical efficacy is often compromised due to chemoresistance. In this study, we investigate the role of TOP2A O-GlcNAcylation in breast cancer cells and patient tumor tissues. Our results demonstrate that elevated TOP2A, especially its...

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PMID: 37249035
DOI: 10.15252/embr.202256458

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