Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis

Abstract excerpt

TO THE EDITOR: Increased fetal hemoglobin (HbF) leads to diminished severity of sickle cell disease (SCD), as HbF disrupts deoxygenated sickle hemoglobin polymerization.[1][1] Many efforts have been made to identify an effective way to increase HbF in adults that include using chemical inducers,[2

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