Article

Chemical Synthesis of Oligosaccharides Derived from <i>Streptococcus pneumoniae</i> Serotype 35B and D to Investigate Binding of Complement and Serum Factors

2025-01-28

Abstract excerpt

<h4>ABSTRACT</h4> The wide use of Streptococcus pneumoniae capsular polysaccharide (CPS) conjugate vaccines is causing serotype replacement and the emergence of serotype 35B is concerning because of its multidrug resistance. CPS of 35B is composed of pentasaccharide repeating units that are linked through phosphodiester linkages. One of the galactofuranose residues of the pentasaccharide is acetylated, which dis...

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Literature Corpus work: 005ba4cf-fbef-5807-a6e5-6f67eab15fae
DOI: 10.1101/2025.01.28.635287

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