Deciphering Antigenic Determinants of <i>Streptococcus pneumoniae</i> Serotype 4 Capsular Polysaccharide using Synthetic Oligosaccharides

Abstract excerpt

Streptococcus pneumoniae is a major cause of mortality and morbidity worldwide. More than 90 S. pneumoniae serotypes are distinguished based on the structure of their primary targets to the human immune system, the capsular polysaccharides (CPSs). The CPS of the prevalent serotype 4 (ST4) is composed of tetrasaccharide repeating units and is included in existing pneumococcal vaccines. Still, the structural...

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