Article

Regulation of HDAC2-PDX1 by RNF125 defines pancreatic cancer development

2020-01-07

Abstract excerpt

There is an urgent need to define mechanisms underlying pancreatic adenocarcinoma (PDA) development. Our studies of ubiquitin ligases that may underlie PDA development led us to identify and characterize RNF125. We show that RNF125 exhibits nuclear expression in acinar cells, with reduced and largely cytosolic expression in ductal cells, PanIN and PDA specimens. We find that RNF125 interacts with histone deacetyla...

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Literature Corpus work: 0059a064-710f-58fb-aeb9-21acf2b5758a
DOI: 10.1101/2020.01.06.896555

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