Article

Ceramide synthase 6 (CerS6) promotes alcohol-induced fatty liver by promoting metabolic dysfunction and upregulating lipid droplet-associated proteins

2022-11-04

Abstract excerpt

<h4>Objective</h4> Alcohol-associated liver disease (ALD) is the leading cause of liver-related mortality worldwide. Current strategies to manage ALD largely focus on advanced stage disease, however, metabolic changes such as glucose intolerance are apparent at the earliest stage of alcoholic steatosis and increase the risk of disease progression. Ceramides impair insulin signaling and accumulate in ALD, and meta...

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Literature Corpus work: 004df342-5788-5775-ba85-3716b60893d4
DOI: 10.1101/2022.11.03.514971

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