Article
Astroglial Connexins Inactivation Increases Relapse of Depressive-like Phenotype after Antidepressant Withdrawal.
International journal of molecular sciences - 30 Oct 2022
Portal Benjamin, Vasile Flora, Zapata Jonathan, Lejards Camille, Ait Tayeb Abd El Kader, Colle Romain, Verstuyft Céline, Corruble Emmanuelle, Rouach Nathalie, Guiard Bruno P
Abstract excerpt
Studies suggest that astrocytic connexins (Cx) have an important role in the regulation of high brain functions through their ability to establish fine-tuned communication with neurons within the tripartite synapse. In light of these properties, growing evidence suggests a role of Cx in psychiatric disorders such as major depression but also in the therapeutic activity of antidepressant drugs. However, the real...
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