Article

LY6E protects mice from pathogenic effects of murine coronavirus and SARS-CoV-2

2023-01-26

Abstract excerpt

LY6E is an antiviral protein that inhibits coronavirus entry. Its expression in immune cells allows mice to control murine coronavirus infection. However, it is not known which immune cell subsets mediate this control or whether LY6E protects mice from SARS-CoV-2. In this study, we used tissue-specific Cre recombinase expression to ablate Ly6e in distinct immune compartments or in all epiblast-derived cells, and...

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Literature Corpus work: 0022809c-8dc3-586d-a6c6-9e292dccca5b
DOI: 10.1101/2023.01.25.525551

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