Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa.

International journal of antimicrobial agents - 1 May 2003

Higgins P G, Fluit A C, Milatovic D, Verhoef J, Schmitz F-J

Abstract excerpt

The target enzymes GyrA and ParC and two efflux pump regulatory genes mexR and nfxB were analysed to determine changes associated with fluoroquinolone resistance in Pseudomonas aeruginosa. Both low- and high-level ciprofloxacin resistance was associated with a Thr-83Ile substitution in GyrA. A Pa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to Ciprofloxacin
Share to DNA Gyrase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Topoisomerase IV

Share to Drug Resistance, Multiple, Bacterial

Share to Microbial Sensitivity Tests

Share to Pseudomonas aeruginosa

Share to Repressor Proteins

Source

Identifiers

PMID: 12727072
DOI: 10.1016/s0924-8579(03)00009-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12727072-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa.PMID 12727072Read ↗

Alterations in the GyrA and GyrB subunits of topoisomerase II and the ParC and ParE subunits of topoisomerase IV in ciprofloxacin-resistant clinical isolates of Pseudomonas aeruginosa.Semantic proximity Read ↗

Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa.Semantic proximity Read ↗

Mutations in the gyrA, parC, and mexR genes provide functional insights into the fluoroquinolone-resistant Pseudomonas aeruginosa isolated in VietnamSemantic proximity Read ↗

The role of Gene Mutations (gyrA, parC) in Resistance to Ciprofloxacin in Clinical Isolates of Pseudomonas AeruginosaSemantic proximity Read ↗

Alterations of gyrA, gyrB, and parC and Activity of Efflux Pump in Fluoroquinolone-resistant Acinetobacter baumanniiSemantic proximity Read ↗

The role of gyrA and parC mutations in fluoroquinolones-resistant Pseudomonas aeruginosa isolates from Iran.Semantic proximity Read ↗

Fluoroquinolone resistance in Achromobacter spp.: substitutions in QRDRs of GyrA, GyrB, ParC and ParE and implication of the RND efflux system AxyEF-OprN.Semantic proximity Read ↗

Parallel evolution and local differentiation in quinolone resistance in Pseudomonas aeruginosaSemantic proximity Read ↗

Gene-Gene Interactions Dictate Ciprofloxacin Resistance in Pseudomonas aeruginosa and Facilitate Prediction of Resistance Phenotype from Genome Sequence Data.Semantic proximity Read ↗

Mutations in gyrB play an important role in ciprofloxacin-resistant Pseudomonas aeruginosaSemantic proximity Read ↗

ParC and GyrA may be interchangeable initial targets of some fluoroquinolones in Streptococcus pneumoniae.Semantic proximity Read ↗

Evaluation of fluoroquinolone resistance mechanisms in Pseudomonas aeruginosa multidrug resistance clinical isolates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.