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Article

Hepatitis A virus translation is rate-limiting for virus replication in MRC-5 cells.

Virology - 15 Feb 1999

Funkhouser A W, Schultz D E, Lemon S M, Purcell R H, Emerson S U

Abstract excerpt

Translation of hepatitis A virus (HAV) RNA is controlled by an internal ribosome entry site (IRES) located within the 5' untranslated region (UTR). In some cell types, the characteristically slow growth of HAV may be due to inefficient viral translation. We investigated whether this is true in MRC-5 cells, which are used for vaccine production. We measured the impact of two clusters of mutations in the 5' UTR on...

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Identifiers

PMID: 9986793
DOI: 10.1006/viro.1998.9548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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