A giant protease with potential to substitute for some functions of the proteasome.

doi:10.1126/science.283.5404.978

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Article

A giant protease with potential to substitute for some functions of the proteasome.

Science (New York, N.Y.) - 12 Feb 1999

Geier E, Pfeifer G, Wilm M, Lucchiari-Hartz M, Baumeister W, Eichmann K, Niedermann G

Abstract excerpt

An alanyl-alanyl-phenylalanyl-7-amino-4-methylcoumarin-hydrolyzing protease particle copurifying with 26S proteasomes was isolated and identified as tripeptidyl peptidase II (TPPII), a cytosolic subtilisin-like peptidase of unknown function. The particle is larger than the 26S proteasome and has...

Topics

Acetylcysteine
Alleles
Amino Acid Chloromethyl Ketones
Aminopeptidases
Animals
Cell Survival
Coumarins
Cysteine Endopeptidases
Cytosol
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
Epitopes
Genes, MHC Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydrolysis

Mice

Molecular Weight

Multienzyme Complexes

Oligopeptides

Proteasome Endopeptidase Complex

Source

Open in PubMed

Identifiers

PMID: 9974389
DOI: 10.1126/science.283.5404.978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9974389-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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