Article
Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2008
Huai Jisen, Firat Elke, Nil Ahmed, Million Daniele, Gaedicke Simone, Kanzler Benoit, Freudenberg Marina, van Endert Peter, Kohler Gabriele, Pahl Heike L, Aichele Peter, Eichmann Klaus, Niedermann Gabriele
Abstract excerpt
The giant cytosolic protease tripeptidyl peptidase II (TPPII) has been implicated in the regulation of proliferation and survival of malignant cells, particularly lymphoma cells. To address its functions in normal cellular and systemic physiology we have generated TPPII-deficient mice. TPPII deficiency activates cell type-specific death programs, including proliferative apoptosis in several T lineage subsets and...
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