Article
Mucosal DNA vaccine immunization against measles with a highly attenuated Shigella flexneri vector.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1999
Fennelly G J, Khan S A, Abadi M A, Wild T F, Bloom B R
Abstract excerpt
An intranasal vaccine vector would elicit protective immunity at the respiratory mucosa, the portal of entry and the primary site for replication for measles virus (MV) and other respiratory viruses. In a murine model of pulmonary Shigella, we demonstrate here that a candidate-attenuated Shigella...
Topics
- Administration, Intranasal
- Animals
- Antigens, Viral
- Gene Expression
- Genetic Vectors
- Immunity, Mucosal
- Interferon-gamma
- Lung
- Measles Vaccine
- Mice
- Mice, Inbred BALB C
- Mice, Knockout
- Mice, SCID
- Mutation
- Nucleocapsid Proteins
- Nucleoproteins
- Safety
- Shigella flexneri