Article

Structurally related anticancer activity of flavonoids: involvement of reactive oxygen species generation

2010-03-01

Abstract excerpt

The cytotoxicity and apoptosis induction effect of 23 flavonoids on human leukemia cells (HL-60) were investigated. 3,6-Dihydroxyflavone, luteolin and geraldol showed the most potent cytotoxic effect. By comparing the cytotoxicity of selected molecules that differ in only one structure element, we identified several structural properties important for potent cytotoxic activity, including the presence of 2,3-double...

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Literature Corpus work: cb7b0baf-65a5-5072-a6d9-3370a617b604
DOI: 10.1111/j.1745-4514.2009.00282.x

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