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Article

CCR2-64I polymorphism is not associated with altered CCR5 expression or coreceptor function.

Journal of virology - 1 Mar 1999

Mariani R, Wong S, Mulder L C, Wilkinson D A, Reinhart A L, LaRosa G, Nibbs R, O'Brien T R, Michael N L, Connor R I, Macdonald M, Busch M, Koup R A, Landau N R

Abstract excerpt

A polymorphism in the gene encoding CCR2 is associated with a delay in progression to AIDS in human immunodeficiency virus (HIV)-infected individuals. The polymorphism, CCR2-64I, changes valine 64 of CCR2 to isoleucine. However, it is not clear whether the effect on AIDS progression results from...

Topics

Blood Donors
Cell Line
Chemokines
Genotype
HIV
Humans
Polymorphism, Genetic
Promoter Regions, Genetic
RNA, Messenger
Receptors, CCR2
Receptors, CCR5
Receptors, CXCR4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Chemokine

Receptors, Cytokine

Receptors, HIV

T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 9971830
DOI: 10.1128/JVI.73.3.2450-2459.1999
PMCID: PMC104492

Genes

CCR2
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9971830-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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