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Article

A CCR2-V64I polymorphism affects stability of CCR2A isoform

1 Mar 2004

Abstract excerpt

OBJECTIVE: A valine to isoleucine substitution at position 64 of CCR2 (CCR2-64I) is associated with a delay in progression to AIDS in HIV-1-infected individuals. The aim of the present study is to elucidate the molecular mechanism underlying the effect of this allele. DESIGN: We analysed the effect of the 64I substitution on levels of expression of CCR2A and CCR2B, two CCR2 isoforms produced by alternative...

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Identifiers

PMID: 15075507
DOI: 10.1097/00002030-200403260-00003

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