Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cells.

doi:10.1128/JVI.73.3.2425-2433.1999

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Article

Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cells.

Journal of virology - 1 Mar 1999

Hatada E, Saito S, Fukuda R

Abstract excerpt

A short model genome RNA and also the genome RNA of influenza A virus bearing both 5'- and 3'-terminal common sequences activated the interferon-induced double-stranded-RNA-dependent protein kinase, PKR, by stimulating autophosphorylation in vitro. The activated PKR catalyzed phosphorylation of t...

Topics

Defective Viruses
Enzyme Activation
Eukaryotic Initiation Factor-2
Flavivirus
HeLa Cells
Humans
Influenza A virus
Mutation
Phosphorylation
RNA
Viral Nonstructural Proteins
eIF-2 Kinase

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