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Article

Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cells.

Journal of virology - 1 Mar 1999

Hatada E, Saito S, Fukuda R

Abstract excerpt

A short model genome RNA and also the genome RNA of influenza A virus bearing both 5'- and 3'-terminal common sequences activated the interferon-induced double-stranded-RNA-dependent protein kinase, PKR, by stimulating autophosphorylation in vitro. The activated PKR catalyzed phosphorylation of the alpha subunit of eucaryotic translation initiation factor 2 (eIF2alpha). The NS1 protein efficiently eliminated the...

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Identifiers

PMID: 9971827
DOI: 10.1128/JVI.73.3.2425-2433.1999
PMCID: PMC104489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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