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Article

Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses.

Journal of virology - 1 Jun 2001

Massin P, van der Werf S, Naffakh N

Abstract excerpt

Human influenza A viruses replicate in the upper respiratory tract at a temperature of about 33 degrees C, whereas avian viruses replicate in the intestinal tract at a temperature close to 41 degrees C. In the present study, we analyzed the influence of low temperature (33 degrees C) on RNA replication of avian and human viruses in cultured cells. The kinetics of replication of the NP segment were similar at 33...

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Identifiers

PMID: 11333924
DOI: 10.1128/JVI.75.11.5398-5404.2001
PMCID: PMC114948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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