Article
Immunogenetics of autoimmune diseases in Asian Indians.
Annals of the New York Academy of Sciences - 1 Apr 2002
Mehra N K, Kaur Gurvinder, Kanga Uma, Tandon Nikhil
Abstract excerpt
The HLA class II molecules play a critical role in the processing and presentation of specific peptides derived from autoantigens of pancreatic beta cells or gluten for T cell scrutiny in IDDM and CD. In the present study, extended DR3-positive haplotypes associated with autoimmunity in northern Indian patients have been reported. The haplotype A26-B8-DR3 was the most common autoimmunity-favoring haplotype...
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