Article
Complete sequence of p53 gene in 20 patients with lung cancer: comparison with chemosensitivity and immunohistochemistry.
Medical oncology (Northwood, London, England) - 1 Dec 1998
Brattström D, Bergqvist M, Lamberg K, Kraaz W, Scheibenflug L, Gustafsson G, Inganäs M, Wagenius G, Brodin O
Abstract excerpt
In this study the entire p53 complementary DNA has been sequenced in 20 non-small cell lung carcinomas (NSCLC) and the results correlated with chemosensitivity, immunohistochemistry and clinical data. Ten patients had mutations in p53, 8 missense mutations and 2 nonsense mutations. The method dis...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
- Carcinoma, Non-Small-Cell Lung
- DNA, Complementary
- Drug Resistance
- Drug Resistance, Neoplasm
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Lung Neoplasms
- Male
- Middle Aged