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Article

Duplicated CFTR isoforms in eels diverged in regulatory structures and osmoregulatory functions.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology - 1 Sept 2016

Wong Marty Kwok-Shing, Pipil Supriya, Kato Akira, Takei Yoshio

Abstract excerpt

Two cystic fibrosis transmembrane conductance regulator (CFTR) isoforms, CFTRa and CFTRb, were cloned in Japanese eel and their structures and functions were studied in different osmoregulatory tissues in freshwater (FW) and seawater (SW) eels. Molecular phylogenetic results suggested that the CFTR duplication in eels occurred independently of the duplication event in salmonid. CFTRa was expressed in the...

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Identifiers

PMID: 27322796
DOI: 10.1016/j.cbpa.2016.06.018

Genes

CFTR

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