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Receptor deorphanization in starfish reveals the evolution of relaxin signaling as a regulator of reproduction

25 Feb 2025

Abstract excerpt

BACKGROUND: Relaxins are a family of peptides that regulate reproductive physiology in vertebrates. Evidence that this is an evolutionarily ancient role of relaxins has been provided by the discovery of two relaxin-like gonad-stimulating peptides (RGP1 and RGP2) that trigger spawning in starfish. The main aim of this study was to identify the receptor(s) that mediate(s) the effects of RGP1 and RGP2 in starfish....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 40001176
DOI: 10.1186/s12915-025-02158-2

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