Article
Dancing in the dark? The status of late-onset Alzheimer's disease genetics.
Journal of molecular neuroscience : MN - 1 Oct 2001
Bertram L, Tanzi R E
Abstract excerpt
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. Recent estimates suggest that possibly over 70% of the genetic variance for the disease remains unaccounted for by apolipoprotein E (APOE) and the three known early-onset AD genes (APP, PSEN1, PSEN2). Specifically, one recent segregation analysis predicted the existence of up to four additional susceptibility genes having a similar or...
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