Article
Genome scan on Swedish Alzheimer's disease families.
Molecular psychiatry - 1 Feb 2006
Sillén A, Forsell C, Lilius L, Axelman K, Björk B F, Onkamo P, Kere J, Winblad B, Graff C
Abstract excerpt
Alzheimer's disease (AD) is an age-related disease, which affects approximately 40% of the population at an age above 90 years. The heritability is estimated to be greater than 60% and there are rare autosomal dominant forms indicating a significant genetic influence on the disease process. Despite the successes in the early 1990s when four genes were identified, which directly cause the disease (APP, PSEN1 and...
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