Using loop length variants to dissect the folding pathway of a four-helix-bundle protein.

doi:10.1006/jmbi.1998.2474

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Article

Using loop length variants to dissect the folding pathway of a four-helix-bundle protein.

Journal of molecular biology - 12 Feb 1999

Nagi A D, Anderson K S, Regan L

Abstract excerpt

Rop is a four-helix-bundle protein formed by the association of two helix-loop-helix monomers. The short helix-connecting loop was replaced with a series of polyglycine linkers of increasing length. These mutant proteins all appear to fold via the same general mechanism as that of the wild-type p...

Topics

Escherichia coli
Kinetics
Mutation
Protein Denaturation
Protein Folding
Protein Structure, Secondary
Recombinant Proteins

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