Dimer-to-tetramer transformation: loop excision dramatically alters structure and stability of the ROP four alpha-helix bundle protein.

doi:10.1006/jmbi.1998.1776

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Article

Dimer-to-tetramer transformation: loop excision dramatically alters structure and stability of the ROP four alpha-helix bundle protein.

Journal of molecular biology - 19 Jun 1998

Lassalle M W, Hinz H J, Wenzel H, Vlassi M, Kokkinidis M, Cesareni G

Abstract excerpt

The ROP loop excision mutant RM6 shows dramatic changes in structure and stability in comparison to the wild-type protein. Removal of the five amino acids (Asp30, Ala31, Asp32, Glu33, Gln34) from the loop results in a complete reorganization of the protein as evidenced by single crystal X-ray ana...

Topics

Amino Acid Sequence
Bacterial Proteins
Dimerization
Molecular Sequence Data
Mutation
Protein Folding
RNA-Binding Proteins
Structure-Activity Relationship

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