Article
Determinants of pantropism of the F1-R mutant of Sendai virus: specific mutations involved are in the F and M genes.
Archives of virology - 1 Jan 1998
Okada H, Seto J T, McQueen N L, Klenk H D, Rott R, Tashiro M
Abstract excerpt
Mutations in the fusion, F, protein of Sendai virus resulting in increased cleavability by ubiquitous host protease(s), and mutations in the matrix, M, protein resulting in bipolar budding, are both important determinants for the systemic infection in mice caused by the protease activating pantropic mutant, F1-R. Several mutants of Sendai virus (BY, BF, and KD-M) with phenotypes of bipolar budding and/or...
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