Article
Organ tropism of Sendai virus in mice: proteolytic activation of the fusion glycoprotein in mouse organs and budding site at the bronchial epithelium.
Journal of virology - 1 Aug 1990
Tashiro M, Yamakawa M, Tobita K, Klenk H D, Rott R, Seto J T
Abstract excerpt
Wild-type Sendai virus is exclusively pneumotropic in mice, while a host range mutant, F1-R, is pantropic. The latter was attributed to structural changes in the fusion (F) glycoprotein, which was cleaved by ubiquitous proteases present in many organs (M. Tashiro, E. Pritzer, M. A. Khoshnan, M. Y...
Topics
- Animals
- Blotting, Western
- Bronchi
- Cell Line
- Cell Membrane
- Epithelium
- Male
- Mice
- Mice, Inbred ICR
- Mutation
- Organ Culture Techniques
- Organ Specificity
- Parainfluenza Virus 1, Human
- Protein Processing, Post-Translational
- Viral Fusion Proteins