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Article

Organ tropism of Sendai virus in mice: proteolytic activation of the fusion glycoprotein in mouse organs and budding site at the bronchial epithelium.

Journal of virology - 1 Aug 1990

Tashiro M, Yamakawa M, Tobita K, Klenk H D, Rott R, Seto J T

Abstract excerpt

Wild-type Sendai virus is exclusively pneumotropic in mice, while a host range mutant, F1-R, is pantropic. The latter was attributed to structural changes in the fusion (F) glycoprotein, which was cleaved by ubiquitous proteases present in many organs (M. Tashiro, E. Pritzer, M. A. Khoshnan, M. Yamakawa, K. Kuroda, H.-D. Klenk, R. Rott, and J. T. Seto, Virology 165:577-583, 1988). These studies were extended by...

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Identifiers

PMID: 2164589
DOI: 10.1128/JVI.64.8.3627-3634.1990
PMCID: PMC249655

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