Article
5-HT4 receptors: cloning and expression of new splice variants.
Annals of the New York Academy of Sciences - 15 Dec 1998
Claeysen S, Faye P, Sebben M, Taviaux S, Bockaert J, Dumuis A
Abstract excerpt
On the basis of differences in the potencies and intrinsic activity of 5-HT4 receptor agonists in different biological models it has been suggested that there is heterogeneity among 5-HT4 receptors. Here, we report the molecular cloning of several 5-HT4 receptor splice variants in mouse, rat, and human brain. Our data suggest that the differences in efficacy of 5-HT4 ligands on 5-HT4 receptor-mediated responses...
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