Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preimplantation single-cell analysis of multiple genetic loci by whole-genome amplification.

21 Jun 1994

Abstract excerpt

Due to the limited amount of DNA in a single diploid cell, preimplantation genetic diagnosis has relied on single- or dual-locus analyses in biopsied blastomers. We have applied single-cell whole-genome preamplification to PCR-based analysis of multiple disease loci from the same diploid cell. This method allows diagnosis of multiple disease genes, analysis of multiple exons/introns within a gene, or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Parvovirus B19 Infection Studies
Share to Prenatal Screening and Diagnostics
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7517043
DOI: 10.1073/pnas.91.13.6181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preimplantation single-cell analysis of multiple genetic loci by whole-genome amplification.PMID 7517043Read ↗

Strategies for preimplantation genetic diagnosis of single gene disorders by DNA amplificationSemantic proximity Read ↗

Preimplantation diagnosis by whole-genome amplification, PCR amplification, and solid-phase minisequencing of blastomere DNA.Semantic proximity Read ↗

Preimplantation genetic diagnosis guided by single-cell genomicsSemantic proximity Read ↗

Improved multiple displacement amplification with phi29 DNA polymerase for genotyping of single human cells.Semantic proximity Read ↗

Whole genome amplification from single cells in preimplantation genetic diagnosis and prenatal diagnosisSemantic proximity Read ↗

Single cell genomics to study DNA and chromosome changes in human gametes and embryos.Semantic proximity Read ↗

Development and validation of concurrent preimplantation genetic diagnosis for single gene disorders and comprehensive chromosomal aneuploidy screening without whole genome amplificationSemantic proximity Read ↗

Preimplantation genetic haplotyping: 127 diagnostic cycles demonstrating a robust, efficient alternative to direct mutation testing on single cells.Semantic proximity Read ↗

Detailed chromosomal and molecular genetic analysis of single cells by whole genome amplification and comparative genomic hybridisationSemantic proximity Read ↗

Genome-Wide Disease Screening in Early Human Embryos with Primary Template-Directed AmplificationSemantic proximity Read ↗

Whole genome amplification from a single cell: a new era for preimplantation genetic diagnosis.Semantic proximity Read ↗

Preimplantation genetic diagnosis of single-gene disorders: experience with more than 200 cycles conducted by a reference laboratory in the United StatesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.