Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for Involvement of Yeast Proliferating Cell Nuclear Antigen in DNA Mismatch Repair

1 Nov 1996

Abstract excerpt

DNA mismatch repair plays a key role in the maintenance of genetic fidelity. Mutations in the human mismatch repair genes hMSH2, hMLH1, hPMS1, and hPMS2 are associated with hereditary nonpolyposis colorectal cancer. The proliferating cell nuclear antigen (PCNA) is essential for DNA replication, where it acts as a processivity factor. Here, we identify a point mutation, pol30-104, in the Saccharomyces cerevisiae...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genetic factors in colorectal cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8910404
DOI: 10.1074/jbc.271.45.27987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for Involvement of Yeast Proliferating Cell Nuclear Antigen in DNA Mismatch RepairPMID 8910404Read ↗

Role of proliferating cell nuclear antigen interactions in the mismatch repair-dependent processing of mitotic and meiotic recombination intermediates in yeast.Semantic proximity Read ↗

Isolation and characterization of new proliferating cell nuclear antigen (POL30) mutator mutants that are defective in DNA mismatch repair.Semantic proximity Read ↗

Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability.Semantic proximity Read ↗

Multiple factors insulate Msh2-Msh6 mismatch repair activity from defects in Msh2 domain I.Semantic proximity Read ↗

Genomic Instability Promoted by Overexpression of Mismatch Repair Factors in Yeast: A Model for Understanding Cancer ProgressionSemantic proximity Read ↗

MLH1, PMS1, and MSH2 Interactions During the Initiation of DNA Mismatch Repair in YeastSemantic proximity Read ↗

Human Mismatch Repair Protein MSH6 Contains a PWWP Domain That Targets Double Stranded DNASemantic proximity Read ↗

Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repairSemantic proximity Read ↗

Novel dominant mutations in Saccharomyces cerevisiae MSH6.Semantic proximity Read ↗

Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae.Semantic proximity Read ↗

Editing DNA replication and recombination by mismatch repair: from bacterial genetics to mechanisms of predisposition to cancer in humans.Semantic proximity Read ↗

Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.